Utility of Xpert® HPV for cervical cancer screening of HIV-positive women
نویسندگان
چکیده
HIV-positive women are at high risk for HPV-related disease as a result of both behavioural and biological factors. More advanced HIV infection is associated with increased risk, while combination antiretroviral therapy (cART) reduces but does not eliminate the excess risk compared to HIV-negative women. We sought to evaluate the clinical utility of screening HIV-positive women using Cepheid GeneXpert® (Xpert® HPV), a real-time cartridge-based nucleic acid amplification test (NAAT) assay which enables partial genotyping based on detecting 14 high-risk HPV types, grouped into five channels, covering types 16, 18/45, 31/33/35/52/58, 51/59 and 39/56/66/68, respectively.
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